Ingredients

ACTIVE INGREDIENTS:

Mintiva Pain Relief Products Active Ingredient - Trolamine Salicylate (10%)

Mintiva products that contain the active ingredient trolamine salicylate: 
      Specialty products (TMJ, Hand, Foot, Back & Neck)
      General Pain products
      Sport Performance Technology

Trolamine salicylate is an organic salt formed by the combination of triethanolamine and salicylic acid (aspirin), and is commonly used in analgesics and sunscreens. It has no odor, which patients prefer, compared to the strong odor of many other analgesics.

Salicylic acid, the analgesic component of trolamine salicylate, was originally isolated from willow bark and has been used for its analgesic (pain relieving), antipyretic (fever reducing), and anti-inflammatory properties for thousands of years. It is used today in prescription and over-the-counter (OTC) products. 

Salicylic acid can be used in its pure form or as a salt or ester such as benzoic acid, methyl salicylate, and other compounds. Methyl salicylate (oil of wintergreen) is another common salicylate used as an external (topical) analgesic, however its strong smell and counterirritant properties are unfavorable for many patients. Methyl salicylate acts as a rubefacient, as do capsaicin, menthol, and rubbing alcohol, which causes redness of the skin and vasodilation. There is limited evidence of the efficacy of methyl salicylate as an analgesic and it is commonly combined with other analgesics. 

Trolamine salicylate is registered under the OTC monograph for external analgesics for the “temporary relief of minor aches and pains associated with arthritis, back and neck pain, muscular aches, neuralgia, bursitis, joint pain, leg and knee pain, tendonitis, cramps, and sports injuries.” 

Studies comparing the absorption, metabolism and excretion of transdermal applications of trolamine salicylate and methyl salicylate indicate that trolamine salicylate provides significantly more bioavailable salicylic acid to the muscles and is excreted more slowly than methyl salicylate (1, 2). While methyl salicylate is excreted at a rapid rate, and a large portion of the drug is excreted unmetabolized, trolamine salicylate is absorbed rapidly into the muscle tissue and metabolized slowly over a longer period of time — trolamine has been shown to have twice the bioequivalence of methyl salicylate in vivo and in vitro (2). Trolamine salicylate also has shown a superior safety profile to methyl salicylate in comprehensive safety studies (3). Thus, trolamine salicylate was chosen as the preferred active ingredient for Mintiva products based on significant safety and efficacy data compared with competing external analgesics.

Heat Therapy Active Ingredients - Menthol (3.0%), Capsicum (0.04%), 

Mintiva products containing menthol and capsicum: 
      Heat Therapy products
      CORE Sport Heat Therapy

Menthol is an organic compound made synthetically or obtained from peppermint or other mint oils. Menthol is used as a topical analgesic to relieve minor aches and pains such as muscle cramps, sprains, headaches and similar conditions, alone or combined with chemicals like camphor, eucalyptus oil or capsaicin. Menthol has analgesic properties that are mediated through a selective activation of K-opioid receptors.

Capsicum (Capsaicin) is the active component of chili peppers, which are plants belonging to the genus Capsicum. It is an irritant for mammals, including humans, and produces a sensation of heat or burning in any tissue with which it comes into contact. Capsicum is currently used in topical ointments to relieve the pain of peripheral neuropathy such as post-herpetic neuralgia caused by shingles or as a cream for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, strains and sprains, often in compounds with other rubefacients. 


NATURAL, BOTANICAL, and/or INACTIVE INGREDIENTS:

Mintiva's products contain a proprietary blend of the following natural, botanical, and/or inactive ingredients. Some products may have various levels of these ingredients, and various combinations of these ingredients. Additional inactive ingredients not listed here may also be included in the formulation. Check the product's label for more information and to see a complete list of ingredients for each product.

Methysulfonylmethane (MSM) is commonly used to help treat or prevent arthritis. MSM is the active component of widely-used anti-inflammatory agent dimethyl sulfoxide (DMSO), exhibits penetration-enhancing, anti-inflammatory, and anti-oxidant effects.

Peppermint oil has a long history as an external analgesic; it contains menthol and has a cooling effect on the skin.

Arnica Montana is commonly used in liniment and ointment preparations used for strains, sprains, and bruises. Commercial arnica preparations are frequently used by professional athletes. The thymol derivatives concentrated in the plants' roots have been clinically shown to be effective vasodilators of subcutaneous blood capillaries. Arnica preparations used topically have been demonstrated to act as an anti-inflammatory and assist in normal healing processes by facilitating transport of blood and fluid accumulations through a dilating action of subcutaneous blood capillaries.

Salix Alba (Willow Bark) had been used for hundreds of years for its analgesic and anti-inflammatory effects. Salicylic acid was discovered to be the active component of the plant, and gave birth to the widespread use of aspirin that we know today.

Aloe Vera extract (pure, grown right at our manufacturing facility in Oklahoma) has been used for hundreds of years for its wound-healing, moisturizing, and antibacterial properties.

Hypericum Perforatum (St. John’s Wort) is an anti-inflammatory compound with significant wound-healing effects. H. Perforatum is a potent inhibitor of prostaglandin E2, and has been tested as a treatment for cancer, immunological disorders, and depression (4).

Centaurea Cyanus extract has been shown to have significant anti-edema, anti-inflammatory, and skin protectant action in multiple animal models (5).

Anthemis Nobilis extract has been used for hundreds of years as a natural antihistamine, and has been shown to exert significant anti-inflammatory effects (6).Witch Hazel hazel is a natural astringent extracted from the bark and leaves of the plant of the same name. Witch hazel is used as a vasoconstrictor, astringent, and skin protectant commonly used in treatments for hemorrhoids and acne. 

Matricaria Chamomilla (Wild Chamomile) is an anti-inflammatory and bactericidal extract and has been used medicinally against sore stomach, irritable bowel syndrome, and as a gentle sleep aid.

Tilia Sylvestris (Linden) has shown to have anti-inflammatory and wound-healing properties.

Calendula Officinalis (Echinacea) extract is used for the treatment of skin disorders and pain, and as a bactericide, antiseptic and anti-inflammatory. The petals and pollen contain triterpenoid esters (an anti-inflammatory) and the carotenoids flavoxanthin and auroxanthin (antioxidants, and the source of the yellow-orange coloration). The leaves and stems contain other carotenoids, mostly lutein (80%) and zeaxanthin (5%), and beta-carotene. Plant extracts are also widely used by cosmetics, presumably due to presence of compounds such as saponins, resins and essential oils.

Sources: 

1. Baldwin JR, Carrano RA, Imondi AR. Penetration of trolamine salicylate into the skeletal muscle of the pig. Journal of Pharmaceutical Sciences 1983; 73: 1002-1004.
2. Cross SE, Anderson S, Roberts MS. Topical penetration of commercial salicylate esters and sals using human isolated skin and clinical microdialysis studies. Br J Clin Pharmacol 1998; 46: 29-35.
3. Cosmetic Ingredient Review Expert Panel. Safety assessment of salicylic acid, butyloctyl salicylate, calcium salicylate, C12-15 alkyl salicylate, capryloyl salicylic acid, hexyldodecyl salicylate, isocetyl salicylate, magnesium salicylate, MEA_salicylate, ethylhexyl salicylate, potassium salicylate, methyl salicylate, myristyl salicylate, sodium salicylate, TEA-salicylate, and tridecyl salicylate. Int J Toxicol 2003; 22 Suppl 3:1-108.
4. Hammer KD, Hillwig ML, Solco AK, Dixon PM, Delate K, Murphy PA, Wurtele ES, Birt DF. Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells. J Agric Food Chem 2007; 55(18): 7323-31.
5. Garbacki N, Gloaguen V, Damas J, Bodart P, Tits M, Angenot L. Anti-inflammatory and immunological effects of Centaurea cyanus flower-heads. J Ethnopharmacol 1999; 68(1-3): 235-41.
6. Rossi T, Melegari M, Bianchi A, Albasini A, Vampa G. Sedative, anti-inflammatory and anti-diuretic effects induced in rats by essential oils of varieties of Anthemis nobilis: a comparative study. Pharmacol Res Commun 1988; 20 Suppl 5: 71-4.